《美國職業棒球大聯盟2K12》是該棒球系列2012年最新作品，游戲的整體畫面清新簡明，給人一種很愉快的感覺，游戲的引擎依舊很強大，玩家可以體驗流暢自然的比賽操作感受，修改器添加了22項功能。

修改內容：

Batting Contact
Batting Power
Bunt Contact
Bunt Success
Batter Eye Frequency
Pitch Meter Speed
Pitch Speed
Pitch Break Influence
Pitcher Composer Influence
Pitcher Control
Throw Accuracy
Gather Error Frequency
Throwing Error Frequency
Outfield Throw Speed
Infield Throw Speed
Outfield Run Speed
Infield Run Speed
Base Runner Speed
Pickoff Success
Catcher Arm Strength
Catcher Arm Accuracy
MP點數一
MP點數二
MP點數三
MP點數四